# LCMS Convention Workbook_St. Louis Missouri_2007_S394 # Machine transcription, uncorrected — CHI Digital Archive (demonstration) 394 THEOLOGICAL DOCUMENTS—COMMISSION ON THEOLOGY AND CHURCH RELATIONS could only be given if we were certain that these lives lack full moral significance. But we do not have this moral certainty. Concerning options one and two, we strongly urge couples not to put themselves in this position. They should make provision for all their viable embryos to be transferred. They will in this way not be faced with decisions to leave their embryos with indefinite fu- tures nor to let them expire. But what about the thousands of embryos with no future prospects? Some will argue that they should remain in indefinite suspended animation in the hope that we may find a moral course for their futures. Others may urge that respect for these lives will mean facing up to a tragic necessity of letting them expire. Our ad- vice to fellow Christians is that couples seek through pregnancy or through embryo adoption to find a living future for any embryos they have produced. Implications for Public Debate We suggest that Christians familiarize themselves with the cur- rent and changing state of debate concerning embryonic stem cell research. We have offered an approach that we think can help Chris- tians engage others in serious reflection upon respect for human life. Citizens in a democracy also have the opportunity and respon- sibility to participate in the political processes of their country. Em- bryonic stem cell research is an issue that will be contested in many different ways in North America. Christians will have occasions in the coming days and years to play their part in helping their coun- tries fashion defensible policies. Human embryos, beginning with conception, are set on a course of development that leads continuously to an unfolding of a unique human life. Consequently, biblically disciplined moral reasoning puts the burden of proof on those who would deny protection to cer- tain embryos. And that burden has not been carried by any of the arguments that have been offered. We have found no moment in this unfolding where a convincing line can be drawn between em- bryonic life that need not be protected and embryonic or fetal or live-born life that should be protected. Science and philosophy have not been able to agree on any punctuation point in human develop- ment for drawing a moral line. Furthermore, the Bible speaks of God’s love and care for an individual from even before the earliest physical moment. We therefore apply the principle “Always to care, never to kill” to pre-implantation human life. Glossary” Adult stem cell—An undifferentiated cell found in a differentiated tissue that can renew itself and (with certain limitations) differentiate to yield all the specialized cell types of the tissue from which it originated. Artificial Insemination (AI)—A technique that introduces sperm into a woman’s body by some means other than sexual intercourse. Sperm often comes from the woman’s husband (AIH), but donor sperm from outside a marriage is also used (AID).** Astrocyte—One of the large neuroglia cells of neural tissues. Blastocyst—A preimplantation embryo of about 150 cells. The blastocyst consists of a sphere made up of an outer layer of cells (the trophectoderm), a fluid-filled cavity (the blastocoel), and a cluster of cells on the interior (the inner cell mass). Bone marrow stromal cells—A stem cell found in bone marrow that generates bone, cartilage, fat, and fibrous connective tissue. Cell division—Method by which a single cell divides to create two cells. This continuous process allows a population of cells to increase in number or maintain its numbers. Cell-based therapies—treatment in which stem cells are induced to differentiate into the specific cell type required to repair damaged or depleted adult cell populations or tissues. 2007 Convention Workbook Cell culture—Growth of cells in vitro on an artificial medium for experimental research. Clone—A line of cells that is genetically identical to the originating cell; in this case, a stem cell. Cryopreservation—Preservation (as of cells) by subjection to extremely low temperatures.* Culture medium—tThe broth that covers cells in a culture dish, which contains nutrients to feed the cells as well as other growth factors that may be added to direct desired changes in the cells. Differentiation—The process whereby an unspecialized early embryonic ‘cell acquires the features of a specialized cell such as a heart, liver, or muscle cell. Directed differentiation—Manipulating stem cell culture conditions to induce differentiation into a particular cell type. DNA—Deoxyribonucleic acid, a chemical found primarily in the nucleus of cells. DNA carries the instructions for making all the structures and materials the body needs to function. Ectoderm—Upper, outermost layer of a group of cells derived from the inner cell mass of the blastocyst; it gives rise to skin, nerves, and brain. Embryo—lIn humans, the developing organism from the time of fertilization until the end of the eighth week of gestation, when it becomes known as a fetus. Embryoid bodies—Clumps of cellular structures that arise when embryonic stem cells are cultured. Embryonic germ cells—cCells found in a specific part of the embryo/fetus called the gonadal ridge that normally develop into mature gametes. Embryonic stem cells—Primitive (undifferentiated) cells from the embryo that have the potential to become a wide variety of specialized cell types. Embryonic stem cell line—Embryonic stem cells, which have been cultured under in vitro conditions that allow proliferation without differentiation for months to years. Endoderm—Lowcr layer of a group of cells derived from the inner cell mass of the blastocyst; it gives rise to lungs and digestive organs. Feeder layer—Cells used in co-culture to maintain pluripotent stem cells. Cells usually consist of mouse embryonic fibroblasts. Fertilization—The process whereby male and female gametes unite. Fetus—A developing human from usually two months after conception to birth. Gamete—A mature male or fernale germ cell (sperm or egg). These cells contain only one-half of the paired genes found in other bodily cells, and they are capable of forming a new and physically unique individual by fusion with a gamete of the opposite sex.** Gene—A functional unit of heredity that is a segment of DNA located in a specific site on a chromosome. A gene directs the formation of an enzyme or other protein. Genetic Science—The systematic study of how genes govern physical development, sometimes simply called genetics. ** Hematopoietic stem cell—A stem cell from which all red and white blood cells develop. Homeostasis—A relatively stable state of equilibrium or a tendency toward such a state between the different but interdependent elements or groups of elements of an organism, population, or group.*